Endocrine Abstracts

Introduction: The impairment of liver function and enhancement for NAFLD development may be attributed to the ubiquitous exposure to endocrine disrupting chemicals such as phthalates. In this study the urinary levels of monoethyl phthalate (MEP) and mono-(2-ethylhexyl) phthalate (MEHP) were compared with the parameters of hepatic function and lipids in overweight, diabetic patients and normal weight population.Methods and patients: In 305 volunteers of b...

Although chronic hypoparathyroidism is known to negatively affect health-related quality of life (HRQoL), burden of illness is less well defined in patients whose disease is not adequately controlled on conventional therapy. We report burden of illness for the European subset of a patient survey in 13 countries globally. 398 adults with chronic hypoparathyroidism not adequately controlled on conventional therapy (recruited by treating physician or patient association) complete...

Background: Patients with pituitary tumour live with life-long consequences of their disease. The first year after pituitary surgery represents a time period of symptoms, fear of tumour recurrence, existential concerns as well as extensive medical evaluations and decisions about hormone replacement. To increase wellbeing, a person-centred care practice up to 1 year after pituitary surgery covering self-management support, accessibility and continuity has been implemented and a...

Standard therapy (ST) for chronic hypoparathyroidism (HPT) includes calcium and active vitamin D supplementation, which can be associated with an increased risk of renal complications. This study compared renal function change, assessed by estimated glomerular filtration rate (eGFR) over 5 years between HPT patients receiving rhPTH1-84 as an adjunct to ST and a historical control cohort without rhPTH1-84. rhPTH1-84-treated HPT patients were selected from two single-arm, long-t...

Introduction: The coexistence of primary hyperparathyroidism with autoimmune diseases is described very rarely in the literature so far. There are only few cases of immune-mediated hyperparathyroidism, associated with anti-calcium- sensing receptor autoantibodies, frequently in context with other immune diseases. Spontaneous remission of primary hyperparathyroidism in anti-TNF therapy of psoriatic arthritis has also been described in one case. Prevalence of positive antithyroi...

Significant knowledge gaps exist regarding the humanistic effects of chronic hypoparathyroidism (HPT), a rare, debilitating condition. We provide interim results from a global survey conducted to characterise the burden associated with chronic HPT from the patient perspective. An anonymous, self-reported survey (online or paper) was conducted in patients with chronic HPT, not adequately controlled with standard therapy by self-perception, from 12 countries through physicians o...

IntroductionThe connection between obesity and tumorigenesis has been well established.AimThe aim of this study was to elucidate if there are any demographic and functional differences in adrenal incidentalomas (AI) with respect to different body mass index (BMI) categories.Patients and methodsThis was an observational, cross sectional study. The AI cohort consist...

Background: Premenstrual syndrome (PMS) and mental health disturbances have been identified as cardiovascular risk factors.Objectives: To determine the effects of Sars-CoV-2 infection on PMS and mental health.Methods: An anonymous survey about reproductive and mental health was shared with women of reproductive age between May and December, 2022. All women used their menstrual cycle (MC) diary while filling out the survey. Surveys ...

Introduction: An insulinoma is a neuroendocrine tumor, deriving mainly from pancreatic islet cells, that constantly produces insulin even when blood sugar is very low. Insulinomas are the most common cause of hypoglycemia resulting from endogenous hyperinsulinism. Biochemical diagnosis of insulinoma is established during prolonged fasting test (up to 72 hours) in 95 % of patients, 90-95% of insulinomas can be diagnosed during 48 hours of prolonged fasting. After biochemical co...

Introduction: Growth response in GH deficient children during GH replacement therapy rarely fulfil our projections and patient’s expectations. We here report three cases with outstanding growth response.Case reports: First patient was diagnosed as gluten enteropathy in early childhood, but the diet didn’t improve his growth. At age of 7 years the diagnosis of isolated GH deficiency (GHD) was established and GH substitution therapy introduced. N...